Identification of (-)-cis-6-acetyl-4S-(3-chloro-4-fluoro-benzoylamino)- 3,4-dihydro-2,2-dimethyl-2H-benzo[b]pyran-3S-ol as a potential antimigraine agent

W N Chan; J M Evans; M S Hadley; H J Herdon; J C Jerman; A A Parsons; S J Read; T O Stean; M Thompson; N Upton

doi:10.1016/s0960-894x(98)00728-8

Identification of (-)-cis-6-acetyl-4S-(3-chloro-4-fluoro-benzoylamino)- 3,4-dihydro-2,2-dimethyl-2H-benzo[b]pyran-3S-ol as a potential antimigraine agent

Bioorg Med Chem Lett. 1999 Jan 18;9(2):285-90. doi: 10.1016/s0960-894x(98)00728-8.

Authors

W N Chan¹, J M Evans, M S Hadley, H J Herdon, J C Jerman, A A Parsons, S J Read, T O Stean, M Thompson, N Upton

Affiliation

¹ SmithKline Beecham Pharmaceuticals, Harlow, Essex, UK.

PMID: 10021946
DOI: 10.1016/s0960-894x(98)00728-8

Abstract

Optimisation of novel cis- and trans-4-(substituted-amido)benzopyran-3-ol derivatives has led to the identification of SB-220453 20 with an in vivo pre-clinical CNS profile predictive of potential antimigraine activity.

Publication types

Comparative Study

MeSH terms

Animals
Benzamides / chemistry
Benzamides / pharmacology*
Benzopyrans / pharmacology*
Dose-Response Relationship, Drug
Methylcellulose / pharmacology
Mice
Migraine Disorders / drug therapy*
Rats
Seizures / chemically induced
Seizures / drug therapy
Sumatriptan / pharmacology
Temperature
Time Factors

Substances

Benzamides
Benzopyrans
tonabersat
Sumatriptan
Methylcellulose